Association of toll-like receptor 10 polymorphisms with paediatric idiopathic uveitis in Han Chinese. Issue 10 (4th July 2019)

• Record Type: Journal Article
• Authors: Lv, Meng; Tan, Handan; Deng, Jing; Du, Liping; Su, Guannan; Wang, Qingfeng; Zhong, Zhenyu; Tan, Xiao; Cao, Qingfeng; Kijlstra, Aize; Yang, Peizeng
• Is Part Of: British journal of ophthalmology. Volume 104:Issue 10(2020)
• Page Start: 1467
• Page End: 1471
• Publication Date: 2019-07-04
• Subjects: genetics -- immunology; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjophthalmol-2019-314483
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : Aims: We aimed to determine whether paediatric idiopathic uveitis (PIU) and juvenile idiopathic arthritis associated paediatric uveitis (JIA-PU) have an association with Toll-like receptor 10 ( TLR10 ) gene polymorphisms in Han Chinese. Methods: Ten tag single nucleotide polymorphisms (SNPs) of TLR10 were analysed in 992 PIU patients, 127 JIA-PU patients and 1600 controls using the Sequenom MassARRAY system and iPLEX Gold assay. Genotype and allele frequencies were analysed using the χ2 test. A stratified analysis was performed according to the clinical features of PIU. Results: Increased frequencies of the rs2101521 A allele, rs10004195 A allele, rs11725309 CC genotype and rs6841698 AA genotype were found in PIU patients compared with controls (corrected p values (Pc)=1.81×10 -4, Pc= 1.12×10 -2, Pc=2.41×10 -2 and Pc=3.29×10 -3, respectively). There was no association between these 10 tag SNPs and JIA-PU. In the stratified analysis, the frequency of the rs6841698 A allele was higher in PIU patients with cataract (Pc=1.45×10 -6 ). The frequencies of the rs2101521 A allele and rs6841698 AA genotype were increased in PIU patients with band keratopathy (BK) (Pc=2.32×10 -2, Pc=3.30×10 -3, respectively). Conclusion: TLR10 gene polymorphisms (rs2101521, rs10004195, rs11725309 and rs6841698) confer susceptibility to PIU in Han Chinese. In a stratified analysis, rs2101521 and rs6841698 are associated with PIU with BK, and rs6841698 correlates with PIU with cataract.