CHANGES IN TOTAL AND INNER RETINAL THICKNESSES IN TYPE 1 DIABETES WITH NO RETINOPATHY AFTER 8 YEARS OF FOLLOW-UP. Issue 7 (July 2020)

• Record Type: Journal Article
• Authors: Pinilla, Isabel; Idoipe, Miriam; Perdices, Lorena; Sanchez-Cano, Ana; Acha, Javier; Lopez-Galvez, Maria Isabel; Cuenca, Nicolas; Abecia, Emilio; Orduna-Hospital, Elvira
• Is Part Of: Retina. Volume 40:Issue 7(2020)
• Publication Date: 2020-07
• Subjects: diabetic retinopathy -- ganglion cell layer -- inner nuclear layer -- inner retinal layers -- neurodegeneration -- ophthalmology -- retinal nerve fiber layer -- retinal thickness -- spectral domain optical coherence tomography -- Type 1 diabetes mellitus; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000002576
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To evaluate changes in retinal layer thickness in patients with Type 1 diabetes with no diabetic retinopathy after 8 years of follow-up. Methods: Ninety Type 1 diabetes and 60 control eyes were studied. Changes in the retinal nerve fiber layer, ganglion cell layer, and inner nuclear layer thicknesses in all Early Treatment Diabetic Retinopathy Study areas were evaluated. Results: The mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control group, respectively. In 2009, total retinal thickness was higher in diabetic patients; differences were statistically significant in all except the nasal areas. In both groups, the mean foveal thickness remained the same during the 8 years. Among diabetic patients, there was a significant reduction in total retinal thickness in all areas excluding the outer temporal one; controls only in the inferior areas. The thickness loss was due to the thinning of the inner retinal layers (inner nuclear layer, ganglion cell layer, and retinal nerve fiber layer). The controls showed a significant diminution in the retinal nerve fiber layer and in the ganglion cell layer areas. The inner nuclear layer showed a diminution in the diabetes mellitus group. Conclusion: Before the onset of diabetic retinopathy, Type 1 diabetes patients experience a diminution of their inner retinal layer thicknesses over time, supporting the hypothesis of retinal neurodegeneration. Abstract : After comparing 90 Type I diabetic eyes and 60 control eyes followed up for 8 years, patients experience a diminution of their inner retinal layers over time, supporting the hypothesis of retinal neurodegeneration, after diabetic retinopathy.