Dedifferentiated Carcinoma of the Endometrium Associated With Low-grade Müllerian Adenosarcoma: A Clinicopathologic Case Report Including the Immunohistochemical and Molecular Profile. (March 2020)

• Record Type: Journal Article
• Authors: Bai, Shi; Hutchinson, Lloyd M.; Meng, Xiuling; Bai, Hongwei; Cosar, Ediz F.; Khan, Ashraf; Cornejo, Kristine
• Is Part Of: International journal of gynecological pathology. Volume 39:Number 2(2020)
• Publication Date: 2020-03
• Subjects: Dedifferentiated carcinoma of the endometrium -- Low-grade Müllerian adenosarcoma -- Metastatic carcinoma -- Immunohistochemical and molecular profile -- Next-generation sequencing; Gynecologic pathology -- Periodicals; Gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.10705
• DOI: 10.1097/PGP.0000000000000584
• Languages: English
• ISSNs: 0277-1691

Abstract

Abstract : Dedifferentiated carcinoma is defined as undifferentiated carcinoma coexisting with a second component of FIGO grade 1 or 2 endometrioid carcinoma. It is a rare entity with highly aggressive behavior. Dedifferentiated carcinoma combined with another primary uterine tumor is even rarer. We describe a case containing 3 different morphologies comprised of a dedifferentiated carcinoma associated with a low-grade endometrioid carcinoma coexisting with a low-grade Müllerian adenosarcoma. We also used targeted genomic analysis to show all 3 components arise from the same founding clone and identify novel mutations that drive tumor progression. Abstract : Supplemental Digital Content is available in the text.