Successful Treatment of a Severe Vision-Threatening Paradoxical Tuberculous Reaction with Infliximab: First Pediatric Use. Issue 4 (April 2020)

• Record Type: Journal Article
• Authors: Abo, Yara-Natalie; Curtis, Nigel; Butters, Coen; Rozen, Thomas H.; Marais, Ben J.; Gwee, Amanda
• Is Part Of: Pediatric infectious disease journal. Volume 39:Issue 4(2020)
• Publication Date: 2020-04
• Subjects: tuberculous meningitis -- tuberculosis -- paradoxical reaction -- optochiasmatic arachnoiditis -- infliximab -- thalidomide; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000002578
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : A 7-year-old girl with tuberculous (TB) meningitis developed optochiasmatic arachnoiditis, a vision-threatening paradoxical reaction, after starting TB treatment including adjunctive steroid therapy. She was treated with infliximab with complete recovery. This is the first report of the use of a tissue necrosis factor α inhibitor for the treatment of a severe paradoxical TB reaction in a child.