Anesthesia enhances spontaneous low-frequency oscillations in the brain. Issue 5 (25th March 2020)

• Record Type: Journal Article
• Authors: Zhang, Zhuo; Li, Fuquan; Li, Ming; Hu, Dewen
• Is Part Of: NeuroReport. Volume 31:Issue 5(2020)
• Publication Date: 2020-03-25
• Subjects: anesthetic concentration -- multitaper analysis method -- optical imaging -- spontaneous low-frequency oscillations; Neurosciences -- Periodicals; Nervous system -- Periodicals; Neurophysiology -- Periodicals; Nervous System Diseases -- Periodicals; Nervous System Physiological Phenomena -- Periodicals; Neurosciences -- Periodicals; 616.805
• DOI: 10.1097/WNR.0000000000001418
• Languages: English
• ISSNs: 0959-4965

Abstract

Abstract : The neurophysiological basis of spontaneous low-frequency brain activity has become a major theme in the study of neural function in both humans and animal models. In such studies, the anesthesia model was generally adopted. However, the effects of anesthesia on spontaneous activity remain unclear. In this work, we explored the characteristics of cerebral spontaneous low-frequency activities at different depths of anesthesia in mice. Using Fourier transformation and the multitaper analysis methods, spontaneous low-frequency oscillations (LFOs) in the intrinsic signals of different cerebral regions (artery, vein, and cortex) were extracted and analyzed. Under different concentrations of anesthetic, the frequency of spontaneous LFO signals remained stable, while LFO amplitudes increased with the depth of anesthesia. The results imply that the anesthetic impacts the amplitude of spontaneous LFOs but does not alter the oscillation frequency.