Temporal instability of salience network activity in migraine with aura. Issue 4 (April 2020)

• Record Type: Journal Article
• Authors: Veréb, Dániel; Szabó, Nikoletta; Tuka, Bernadett; Tajti, János; Király, András; Faragó, Péter; Kocsis, Krisztián; Tóth, Eszter; Bozsik, Bence; Kincses, Bálint; Vécsei, László; Kincses, Zsigmond Tamás
• Is Part Of: Pain. Volume 161:Issue 4(2020)
• Publication Date: 2020-04
• Subjects: Migraine -- Functional MRI -- Dynamic functional connectivity -- Salience network; Pain -- Periodicals; Douleur -- Périodiques; Anesthésie -- Périodiques; Pain; Electronic journals; Periodicals; Electronic journals; 616.0472
• DOI: 10.1097/j.pain.0000000000001770
• Languages: English
• ISSNs: 0304-3959

Abstract

Abstract : Abstract: This study aims to investigate whether intranetwork dynamic functional connectivity and causal interactions of the salience network is altered in the interictal term of migraine. Thirty-two healthy controls, 37 migraineurs without aura, and 20 migraineurs with aura were recruited. Participants underwent a T1-weighted scan and resting-state fMRI protocol inside a 1.5T MR scanner. We obtained average spatial maps of resting-state networks using group independent component analysis, which yielded subject-specific time series through a dual regression approach. Salience network regions of interest (bilateral insulae and prefrontal cortices, dorsal anterior cingulate cortex) were obtained from the group average map through cluster-based thresholding. To describe intranetwork connectivity, average and dynamic conditional correlation was calculated. Causal interactions between the default-mode, dorsal attention, and salience network were characterised by spectral Granger's causality. Time-averaged correlation was lower between the right insula and prefrontal cortex in migraine without aura vs with aura and healthy controls ( P < 0.038, P < 0.037). Variance of dynamic conditional correlation was higher in migraine with aura vs healthy controls and migraine with aura vs without aura between the right insula and dorsal anterior cingulate cortex ( P < 0.011, P < 0.026), and in migraine with aura vs healthy controls between the dorsal anterior cingulate and left prefrontal cortex ( P < 0.021). Causality was weaker in the <0.05 Hz frequency range between the salience and dorsal attention networks in migraine with aura ( P < 0.032). Overall, migraineurs with aura exhibit more fluctuating connections in the salience network, which also affect network interactions, and could be connected to altered cortical excitability and increased sensory gain. Abstract : Functional connections of the salience network are less steady in migraineurs with aura, with an impact on between-network connections.