Waterborne and dietary accumulation of well-dispersible hematite nanoparticles by zebrafish at different life stages. (April 2020)

• Record Type: Journal Article
• Authors: Huang, Bin; Cui, Yu-Qing; Guo, Wen-Bo; Yang, Liuyan; Miao, Ai-Jun
• Is Part Of: Environmental pollution. Volume 259(2020)
• Publication Date: 2020-04
• Subjects: Bioaccumulation -- Exposure route -- Hematite nanoparticles -- Life stage -- Zebrafish; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2019.113852
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: The widespread use of nanoparticles (NPs) has drawn considerable attention because of their potential toxicity and the environmental consequences thereof. However, the effects of the exposure route and life stage of an organism on the bioaccumulation and toxicity of NPs are largely unknown. In the present study, we investigated the accumulation kinetics (uptake, assimilation, and efflux) and tissue distribution of waterborne and dietary hematite NPs (HemNPs) during three life stages (embryo, larva, and adult) of the zebrafish Danio rerio . For all zebrafish life stages, the waterborne accumulation of well-dispersed HemNPs increased linearly with exposure time but decreased after reaching a maximum. The increase in HemNPs accumulation followed the order embryo > larva > adult. Compared with the waterborne route, the dietary accumulation of HemNPs in larval and adult zebrafish fluctuated, reaching a maximum after each food refreshment and then decreasing until the next food addition. Similar to waterborne exposure, adult fish accumulated less dietary HemNPs than did larvae. Nevertheless, dietary HemNPs mostly accumulated in the intestinal tract, with smaller amounts in the truncus, head, and gills, as compared with their waterborne counterparts. Moreover, in the gonad no dietary HemNPs were detected whereas accumulation via waterborne HemNPs was significant. Despite the low assimilation efficiency of dietary HemNPs, biodynamic modeling showed that the diet was the main source of particle accumulation in zebrafish. Thus, both the life stage and the exposure route should be considered in evaluations of the environmental risks of NPs. Graphical abstract: Image 1 Highlights: Waterborne accumulation of HemNPs decreased in the order of embryo > larva > adult. Dietary HemNPs accumulation reduced from larva to adult and fluctuated with time. Both waterborne and dietary HemNPs mostly accumulated in the intestinal tract. Dietary route had a main contribution to HemNPs accumulation in zebrafish. Abstract : Capsule: Exposure route and life stage play important roles in nanoparticle accumulation in zebrafish.