Silver(I)‐ and Base‐Mediated formal [4+3] Cycloaddition of in Situ generated 1, 2‐Diaza‐1, 3‐dienes with C, N‐Cyclic Azomethine Imines: An Efficient Protocol for the Synthesis of Tetrazepine Derivatives. Issue 13 (26th May 2020)

• Record Type: Journal Article
• Authors: Li, Zefei; Li, Shuaikang; Kan, Tianjiao; Wang, Xinyue; Xin, Xin; Hou, Yunlei; Gong, Ping
• Is Part Of: Advanced synthesis & catalysis. Volume 362:Issue 13(2020)
• Page Start: 2626
• Page End: 2631
• Publication Date: 2020-05-26
• Subjects: Silver -- 1, 2-Diaza-1, 3-dienes -- Azomethine imines -- [4+3] Cycloaddition -- Tetrazepine derivatives; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202000398
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A silver(I)‐ and base‐mediated formal [4+3] cycloaddition reaction of in situ generated 1, 2‐diaza‐1, 3‐dienes with in situ formed C, N ‐cyclic azomethine imines has been developed. This protocol provided an efficient method for the synthesis of biologically important 1, 2, 4, 5‐tetrazepine derivatives with a wild substrate scope and excellent functional group tolerance in moderate to excellent yields. Abstract :