Design, Synthesis, and Structural Elucidation of New Pyridine and Thienopyridine Derivatives. (10th December 2018)

• Record Type: Journal Article
• Authors: Elsayed, Mohamed A.; Abdel Hafez, Naglaa A.; Elshahawi, Manal M.; Ali, Korany A.
• Is Part Of: Journal of heterocyclic chemistry. Volume 56:Number 1(2019)
• Page Start: 172
• Page End: 179
• Publication Date: 2018-12-10
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.3392
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : New series of 3‐cyanopyridine scaffolds were prepared from the reaction of 3‐(4‐bromophenyl)‐1‐(3, 4‐dimethoxyphenyl)prop‐2‐en‐1‐one with active nitriles, including malononitrile and 2‐cyanothioacetamide. The newly prepared 6‐(4‐bromophenyl)‐4‐(3, 4‐dimethoxyphenyl)‐2‐thioxo‐1, 2‐dihydropyridine‐3‐carbonitrile was used as a scaffold for the preparation of new series of condensed thienopyridines by its reactions with active halo compounds, namely, ethyl chloroacetate, chloroacetonitrile, phenacyl bromide, chloroacetone, and 2‐chloro‐ N ‐arylacetamide. The structures of the synthesized compounds were elucidated by the elemental analysis, spectral data and chemically by their preparations with other pathways. Abstract :