Synthesis of Novel Thiazolidin‐4‐ones and Thiazinan‐4‐ones Analogous to Rosiglitazone. (28th November 2018)

• Record Type: Journal Article
• Authors: das Neves, Adriana M.; Campos, José C.; Gouvêa, Daniela P.; Berwaldt, Gabriele A.; Goulart, Taís B.; Avila, Cinara T.; Machado, Pablo; Zimmer, Geórgia C.; Cunico, Wilson
• Is Part Of: Journal of heterocyclic chemistry. Volume 56:Number 1(2019)
• Page Start: 251
• Page End: 259
• Publication Date: 2018-11-28
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.3402
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : This work reports the synthesis of thiazolidin‐4‐ones and thiazinan‐4‐ones analogous to rosiglitazone, a potent antidiabetic drug. The desired compounds were synthesized with moderate to good yields by one‐pot reactions between different primary amines, mercaptoacetic or mercaptopropionic acids, and the 4‐(2‐(methyl(pyridin‐2‐yl)amino)ethoxy)benzaldehyde. The cyclocondensation reactions were carried out for 20 h, and all the products were characterized by 1 H and 13 C nuclear magnetic resonance spectroscopy, mass spectrometry, and one example by X‐ray diffraction. Abstract :