Convenient Synthesis of Novel Nitrogen Bridgehead Heterocycles Utilizing 3‐Mercapto‐6H‐[1, 2, 4, 5]oxatriazino[3, 2‐a]isoindol‐6‐one as a New Synthon. (27th November 2018)

• Record Type: Journal Article
• Authors: El Azab, Islam H.; Elkanzi, Nadia A. A.; Gobouri, Adil A.; Altalhi, Tariq A.
• Is Part Of: Journal of heterocyclic chemistry. Volume 56:Number 1(2019)
• Page Start: 60
• Page End: 72
• Publication Date: 2018-11-27
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.3370
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : Considering oxatriazino[ a ]isoindole as a wealthy structure for developing molecules of impressive therapeutic potentials, some new oxatriazino[3, 2‐ a ]isoindoles analogs were synthesized. Thus, 3‐mercapto‐6 H ‐[1, 2, 4, 5]oxatriazino[3, 2‐ a ]isoindol‐6‐one (5 ), was prepared as one‐pot three‐components product and subjected to a series of manipulations including cycloaddition reactions to annulate a series of pharmacophoric motif conjugates. The structures of the newly synthesized compounds were elucidated based on their correct elemental and spectroscopic data. Abstract :