Capsaicin induces a protective effect on gastric mucosa along with decreased expression of inflammatory molecules in a gastritis model. (August 2019)

• Record Type: Journal Article
• Authors: Mendivil, Edgar J.; Sandoval-Rodriguez, Ana; Meza-Ríos, Alejandra; Zuñiga-Ramos, Lourdes; Dominguez-Rosales, Alfredo; Vazquez-Del Mercado, Monica; Sanchez-Orozco, Laura; Santos-Garcia, Arturo; Armendariz-Borunda, Juan
• Is Part Of: Journal of functional foods. Volume 59(2019)
• Page Start: 345
• Page End: 351
• Publication Date: 2019-08
• Subjects: Capsaicin -- Gastritis -- Cyclooxygenase-2 -- Proinflammatory cytokines -- Acetylsalicylic acid; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2019.06.002
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Capsaicin down-regulated proinflammatory cytokines in gastric mucosa. Capsaicin reduces inflammatory infiltrate in gastric mucosa. Capsaicin exerted gastric protection against gastric lesions. Capsaicin down-regulated COX-2 in gastric mucosa. Abstract: Capsaicin (CPS) is a pungent compound found in Capsicum annuum that has shown anti-inflammatory properties. About 50% of the worldwide population suffer from gastrointestinal disorders and treatment guidelines restrict chili pepper consumption. Our objective was to evaluate the effect of CPS consumption on stomach mucosa, proinflammatory cytokines ( TNF-α, IL-1β, IL-6 ) and cyclooxygenase-2 enzyme ( COX-2 ) in gastric mucosa of two experimental models. The first one comprised healthy rats treated with vehicle or CPS 2 mg/kg during 8 weeks, to elucidate whether CPS induces inflammation of gastric mucosa. The second study included a 2-weeks gastritis model induced with oral acetylsalicylic acid (ASA) plus vehicle group, ASA+CPS group and healthy control rats to assess the protective effect of CPS. Histopathological and molecular analysis were performed on stomach samples. Our results showed a protective effect on gastric mucosa and a significant down-regulation of proinflammatory cytokines and COX-2 in both experimental models.