Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP. (21st June 2020)

• Record Type: Journal Article
• Authors: Pu, Yaoyu; Chang, Lijia; Qu, Youge; Wang, Siming; Tan, Yunfei; Wang, Xingming; Zhang, Jiancheng; Hashimoto, Kenji
• Is Part Of: Neuroscience letters. Volume 730(2020)
• Publication Date: 2020-06-21
• Subjects: Dopamine transporter -- Glyphosate -- Tyrosine hydroxylase -- Parkinson disease; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2020.135032
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: The herbicide glyphosate has been used widely in the world. Exposure of glyphosate potentiated MPTP-induced dopaminergic neurotoxicity in the mouse brain. Glyphosate exposure may be an environmental risk factor for Parkinson's disease. Abstract: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. Epidemiological studies suggest that the exposure of the herbicide glyphosate may influence the development of PD in humans. In this study, we examined whether the exposure of glyphosate can affect the reduction of dopamine transporter (DAT) in the striatum and tyrosine hydroxylase (TH) in the substantial nigra (SNr) of mouse brain after repeated administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Repeated injections of MPTP (10 mg/kg × 3, 2-h interval) significantly decreased the density of DAT-immunoreactivity in the striatum and the number of TH-immunoreactivity in the SNr. Glyphosate exposure for 14 days significantly potentiated MPTP-induced dopaminergic neurotoxicity in the striatum and SNr of mouse brain. This study suggests that glyphosate exposure might exacerbate MPTP-induced dopaminergic neurotoxicity in the striatum and SNr of adult mice. It is likely that exposure of glyphosate may be an environmental risk factor for PD since glyphosate has been used widely in the world.