Associations between multiple serum metal exposures and low birth weight infants in Chinese pregnant women: A nested case-control study. (September 2019)

• Record Type: Journal Article
• Authors: Hou, Qingzhi; Huang, Lulu; Ge, Xiaoting; Yang, Aimin; Luo, Xiaoyu; Huang, Sifang; Xiao, Yang; Jiang, Chao; Li, Longman; Pan, Zhijian; Teng, Tao; Zhang, Haiying; Li, Mujun; Mo, Zengnan; Yang, Xiaobo
• Is Part Of: Chemosphere. Volume 231(2019)
• Page Start: 225
• Page End: 232
• Publication Date: 2019-09
• Subjects: Serum metals -- Exposure -- Low birth weight -- Nested case-control study; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2019.05.103
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: To investigate the associations between prenatal exposure to single metal and multiple metals and the risk of low birth weight (LBW), we conducted a nested case-control study of 246 LBW and 406 NBW mother-infant pairs based on a prospective birth cohort study. 22 serum metals were detected by inductively coupled plasma quadruple mass spectrometry (ICP-MS). Categorical analyses showed serum Co and Ti were associated with LBW (Co: 3rd vs 4th . quartile: OR = 1.83, 95%CI: 1.14–2.92, P trend = 0.043; Ti: 2nd vs. 4th quartile: OR = 0.51, 95% CI: 0.32–0.81, P trend = 0.051), especially gestational age >13 weeks (Co: 3rd vs. 4th quartile: OR = 1.94, 95% CI: 1.13 - 3.32, P trend = 0.043; Ti: 2nd vs . 4th quartile: OR = 0.50, 95% CI: 0.30 - 0.84, P trend= 0.073). Cubic spline analyses showed serum Co and serum Ti had non-linearity associations with LBW (Co: P for overall = 0.048, P -nonlinearity = 0.014; Ti: P for overall = 0.015, P - nonlinearity = 0.008). In multi-metal compound exposure model, 15 metals selected by elastic net model were significantly associated with the increased risk of LBW and OR (95%CI) was 5.14 (2.81–9.40). Our study suggested that lower level serum Co was positively associated with LBW and lower level serum Ti was negatively associated with LBW, especially gestational age >13 weeks, and both of them had non-linearity dose-relationships with LBW. And multi-metal compound model was significantly associated with LBW compared with single metal model. Highlights: Maternal serum cobalt and titanium had non-linearity dose-response relationships with the risk of low birth weight. The association of serum cobalt and titanium and the risk of low birth weight were different in gestational age, maternal age and infant gender. Multi-metal selected by elastic net regression were negatively associated with the risk of low birth weight. The multi-metal combination exposure model had much better predict effect on the risk of low birth weight than single metal model.