Response assessment in diffuse intrinsic pontine glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Issue 6 (June 2020)

• Record Type: Journal Article
• Authors: Cooney, Tabitha M; Cohen, Kenneth J; Guimaraes, Carolina V; Dhall, Girish; Leach, James; Massimino, Maura; Erbetta, Alessandra; Chiapparini, Luisa; Malbari, Fatema; Kramer, Kim; Pollack, Ian F; Baxter, Patricia; Laughlin, Suzanne; Patay, Zoltán; Young Poussaint, Tina; Warren, Katherine E
• Is Part Of: Lancet oncology. Volume 21:Issue 6(2020)
• Page Start: e330
• Page End: e336
• Publication Date: 2020-06
• Subjects: Oncology -- Periodicals; Neoplasms -- Periodicals; Cancérologie -- Périodiques; Oncologie; Oncology; Periodicals; Electronic journals; 616.994005
• DOI: 10.1016/S1470-2045(20)30166-2
• Languages: English
• ISSNs: 1470-2045

Abstract

Summary: Optimising the conduct of clinical trials for diffuse intrinsic pontine glioma involves use of consistent, objective disease assessments and standardised response criteria. The Response Assessment in Pediatric Neuro-Oncology working group, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radiologists, radiation oncologists, and neurosurgeons, was established to address issues and unique challenges in assessing response in children with CNS tumours. A working group was formed specifically to address response assessment in children and young adults with diffuse intrinsic pontine glioma and to develop a consensus on recommendations for response assessment. Response should be assessed using MRI of brain and spine, neurological examination, and anti-inflammatory or antiangiogenic drugs. Clinical imaging standards are defined. As with previous consensus recommendations, these recommendations will need to be validated in prospective clinical trials.