Is there any link between vitamin D deficiency and vasovagal syncope?. Issue 2 (10th February 2020)

• Record Type: Journal Article
• Authors: Usalp, Songül; Kemal, Hatice; Yüksek, Ümit; Yaman, Belma; Günsel, Aziz; Edebal, Oğuzhan; Akpınar, Onur; Cerit, Levent; Duygu, Hamza
• Is Part Of: Journal of arrhythmia. Volume 36:Issue 2(2020)
• Page Start: 371
• Page End: 376
• Publication Date: 2020-02-10
• Subjects: head‐up tilt table test -- syncope -- vitamin D deficiency; Arrhythmia -- Periodicals; Cardiac pacing -- Periodicals; Arrhythmias, Cardiac; Arrhythmia; Cardiac pacing; Periodicals; Electronic journals; Periodicals; 616.128
• DOI: 10.1002/joa3.12309
• Languages: English
• ISSNs: 1880-4276

Abstract

Abstract: Background: This study aimed to investigate serum 25[OH]D levels between patients with vasovagal syncope (VVS) diagnosed with head‐up tilt table test (HUTT) and age‐matched healthy people. Methods: The study included 75 consecutive patients (32.3 ± 10.7 years), who presented with syncope and underwent HUTT and 52 healthy controls (32.9 ± 14.1 years). HUTT patients were divided into two groups according to whether there was syncope response to the test. Patients underwent cardiac, psychiatric, and neurological investigation. Serum 25[OH]D levels were measured by chemiluminescent microparticle immunoassay method. Results: There was no difference between the two groups in terms of age, gender, body mass index (BMI), echocardiographic findings ( P > .05). Mean serum 25[OH]D (24.5 ± 6.3 vs 20.1 ± 8.8 ng/mL, P = .003) and vitamin B12 levels (436.4 ± 199.2 vs 363.1 ± 107.6 pg/mL, P = .009) was lower in syncope patients when compared to the control group. In correlation analyses, syncope was shown as correlated with the vitamin D ( r = −264, P = .003) and vitamin B12 levels ( r = −233, P = .009). But, multivariate regression analyses showed that only vitamin D increased risk of syncope [OR: 0.946, 95% CI (0.901‐0.994)]. There was no difference in terms of age, gender, BMI, echocardiographic findings between the in HUTT positive (n = 45) and negative groups (n = 29). Only vitamin D level was significantly lower in HUTT positive group (17.5 ± 7.7 vs 24.4 ± 9.1 ng/mL, P = .002). There was no difference among in the vasovagal subgroups in terms of vitamin D level and other features. Conclusion: Vitamin D and B12 levels were reasonably low in syncope patients, but especially low Vitamin D levels were associated with VVS diagnosed in HUTT. Abstract : Various diseases play a role in the etiology of syncope. In our study, we investigated whether there is a relationship between vitamin D and syncope. We found that the frequency of vasovagal syncope was increased especially in female gender and vitamin D levels below 20 mg/dL.