Family history of mood disorders and concomitant psychopathology in patients with depression. (13th April 2021)

• Record Type: Journal Article
• Authors: Kasyanov, E.; Nikolishin, A.; Rukavishnikov, G.; Kibitov, A.; Mazo, G.
• Is Part Of: European psychiatry. Volume 64:Supplement 1(2021)
• Page Start: S338
• Page End: S338
• Publication Date: 2021-04-13
• Subjects: Depression -- anxiety -- family history; Psychiatry -- Periodicals; Mental illness -- Periodicals; Electronic journals; 616.89
• DOI: 10.1192/j.eurpsy.2021.907
• Languages: English
• ISSNs: 0924-9338

Abstract

Abstract : Introduction: A family history (FH) of mood disorders is an important clinical feature that affects the risk of depression and its clinical manifestations during the course of the disease. Objectives: To assess the impact of FH in patients with depression on the presence of concomitant psychiatric disorders. Methods: This cross-sectional study included 172 patients with depression (64.5% women; age - 40, 87±15, 86 years). The M.I.N.I. was conducted to verify the diagnosis of psychiatric disorders. FH is based on indirect reports of patients. Results: The most prevalent concomitant psychiatric diagnoses in patients with depression were generalized anxiety disorder (GAD; 26, 2%), panic disorder (24, 4%) and social anxiety disorder (13, 4%). FH was recorded in 52 (30.2%) patients with depression. Patients with depression and FH more often had concomitant GAD (with FH - 20 (38, 5%), without FH - 25 (20, 8%); p=0.016). Women with depression and FH showed a higher rate of early onset (before age 18) of depression (with FH - 10 (32, 3%), without FH - 10 (12, 5%); p=0.015). Men with depression and FH more often had concomitant GAD (with FH - 10 (47, 6%), without FH - 8 (20%); p=0.025). Logistic regression revealed that FH was associated with GAD in patients with depression (p=0.019). Conclusions: FH of mood disorders in patients with depression is associated with specific concomitant psychopathology. Further genetic studies are needed to explain this comorbidity.