Immunohistology of rheumatoid nodules and rheumatoid synovium. Issue 5 (May 1988)

• Record Type: Journal Article
• Authors: Athanasou, N A; Quinn, J; Woods, C G; Mcgee, J O
• Is Part Of: Annals of the rheumatic diseases. Volume 47:Issue 5(1988)
• Page Start: 398
• Page End: 403
• Publication Date: 1988-05
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.47.5.398
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : The immunohistological features of rheumatoid nodules and rheumatoid synovium were examined using monoclonal and polyclonal antibodies raised against macrophages, HLA-DR, leucocyte common antigen, and immunoglobulin components. The palisading cells surrounding the necrotic centre of the rheumatoid nodule were shown to be HLA-DR positive leucocytes, mostly histiocytes. The inflammatory infiltrate associated with rheumatoid nodules showed many immunohistochemical similarities to that of rheumatoid synovium, including a preponderance of IgG positive plasma cells, and a similar number and microanatomical pattern of distribution of HLA-DR positive cells. The significance of these findings for the cellular immunopathology and aetiology of the rheumatoid lesion is discussed.