45 Preventive effect of Sparassis crispa on type I diabetes. (19th December 2016)

• Record Type: Journal Article
• Authors: Meng, Lingjun; Lu, Jiahui; Meng, Wei; Jiang, Dan; Wang, Di; Quan, Yutong
• Is Part Of: Journal of investigative medicine. Volume 64(2016)Supplement 8
• Page Start: A16
• Page End: A16
• Publication Date: 2016-12-19
• Subjects: Clinical medicine -- Periodicals; Medicine -- Research -- Periodicals; Medicine; Research -- United States; Clinical medicine; Medicine -- Research; Periodicals; 616.075
• DOI: 10.1136/jim-2016-000328.45
• Languages: English
• ISSNs: 1081-5589

Abstract

Abstract : Objectives: The purpose of this study was to investigate the preventive effect of Sparassis crispa on type I diabetes. Methods: The preventive effect of S. crispa extract (0.6 g/kg/day) was investigated using a rat model of type I diabetes established by streptozotocin after 3-week oral administration. The diabetes-related factor index was examined using the ELISA test. Results: Compared to the model group, the S. crispa extract administration group showed lower diabetic weight lost ( p < 0.01), lower fasting glucose levels and lower postprandial 2-hour blood glucose levels ( p < 0.001). S. crispa extract administration can significantly alleviate STZ-induced decrease in glucose tolerance and reduce STZ-induced elevation in endotoxin and iNOS levels. It also effectively suppresses glycosylated hemoglobin accumulation and reduces total bile acid level. Conclusions: S. crispa extract has a good preventive effect on type I diabetes. This study provides a theoretical basis for its use in healthcare products and drugs for type I diabetes.