45 Preventive effect of Sparassis crispa on type I diabetes. (19th December 2016)
- Record Type:
- Journal Article
- Title:
- 45 Preventive effect of Sparassis crispa on type I diabetes. (19th December 2016)
- Main Title:
- 45 Preventive effect of Sparassis crispa on type I diabetes
- Authors:
- Meng, Lingjun
Lu, Jiahui
Meng, Wei
Jiang, Dan
Wang, Di
Quan, Yutong - Abstract:
- Abstract : Objectives: The purpose of this study was to investigate the preventive effect of Sparassis crispa on type I diabetes. Methods: The preventive effect of S. crispa extract (0.6 g/kg/day) was investigated using a rat model of type I diabetes established by streptozotocin after 3-week oral administration. The diabetes-related factor index was examined using the ELISA test. Results: Compared to the model group, the S. crispa extract administration group showed lower diabetic weight lost ( p < 0.01), lower fasting glucose levels and lower postprandial 2-hour blood glucose levels ( p < 0.001). S. crispa extract administration can significantly alleviate STZ-induced decrease in glucose tolerance and reduce STZ-induced elevation in endotoxin and iNOS levels. It also effectively suppresses glycosylated hemoglobin accumulation and reduces total bile acid level. Conclusions: S. crispa extract has a good preventive effect on type I diabetes. This study provides a theoretical basis for its use in healthcare products and drugs for type I diabetes.
- Is Part Of:
- Journal of investigative medicine. Volume 64(2016)Supplement 8
- Journal:
- Journal of investigative medicine
- Issue:
- Volume 64(2016)Supplement 8
- Issue Display:
- Volume 64, Issue 8 (2016)
- Year:
- 2016
- Volume:
- 64
- Issue:
- 8
- Issue Sort Value:
- 2016-0064-0008-0000
- Page Start:
- A16
- Page End:
- A16
- Publication Date:
- 2016-12-19
- Subjects:
- Clinical medicine -- Periodicals
Medicine -- Research -- Periodicals
Medicine
Research -- United States
Clinical medicine
Medicine -- Research
Periodicals
616.075 - Journal URLs:
- http://journals.lww.com/jinvestigativemed/pages/default.aspx ↗
http://jim.bmj.com/ ↗
https://journals.sagepub.com/home/IMJ ↗
http://journals.lww.com ↗ - DOI:
- 10.1136/jim-2016-000328.45 ↗
- Languages:
- English
- ISSNs:
- 1081-5589
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5008.010000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 18654.xml