The Predictive Value of Tumor Size, Volume, and Markers During Radiation Therapy in Patients With Cervical Cancer. Issue 1 (1st January 2016)

• Record Type: Journal Article
• Authors: Lee, Kyu Chan; Kim, Hun Jung; Sung, KiHoon; Choi, Young Eun; Lee, Seok Ho; Lim, Soyi; Lee, Kwang Beom; Shin, Jin Woo; Park, Chan Yong; Kim, Young Saing; Sym, Sun Jin; Shim, Young Sup; Choi, Seung Joon
• Is Part Of: International journal of gynecological cancer. Volume 27:Issue 1(2017)
• Page Start: 123
• Page End: 130
• Publication Date: 2016-01-01
• Subjects: Cervix cancer -- Radiation therapy -- Tumor volume -- Squamous cell carcinoma antigen; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0000000000000837
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Objectives: We investigated the prognostic significance of changes in primary tumor volume and serum squamous cell carcinoma antigen (SCC-ag) levels during radiation therapy (RT) in patients with cervical cancer. Methods: We conducted a review of 40 patients treated with RT. All patients received external beam RT and intracavitary brachytherapy. The primary tumor volume and squamous cell carcinoma antigen levels were measured pre-RT and mid-RT. Overall survival (OS) and progression free survival (PFS) were estimated, and possible prognostic factors for survival were analyzed. Results: The correlation coefficient between primary tumor volume reduction rate (pTVRR) and serum squamous cell carcinoma antigen reduction rate in all patients was 0.550 ( P < 0.001). In univariate analysis, stage more than II ( P <0.001), pre-RT pTV of 55 cm 3 or more ( P = 0.05), mid-RT tumor size of 4 cm or more ( P = 0.004), and pTVRR of 90% or less ( P = 0.031) were significant unfavorable prognostic factors for PFS, whereas stage ( P = 0.009) was the only significant prognostic factor for OS. Multivariable analysis revealed that none of these factors were independently associated with PFS or OS. Conclusions: There was a significant correlation between pTVRR and squamous cell carcinoma antigen reduction rate. Our findings indicate that the tumor parameters such as pre-RT pTV, mid-RT tumor size, and pTVRR are associated with PFS in women with cervical cancer.