Cortical mechanisms in migraine. (19th November 2021)

• Record Type: Journal Article
• Authors: Dai, Wei; Liu, Ren-Hao; Qiu, Enchao; Liu, Yinglu; Chen, Zhiye; Chen, Xiaoyan; Ao, Ran; Zhuo, Min; Yu, Shengyuan
• Is Part Of: Molecular pain. Volume 17(2021)
• Publication Date: 2021-11-19
• Subjects: migraine -- cerebral cortex -- cortical spreading depression -- long-term potentiation -- pathophysiology; Pain -- Molecular aspects -- Periodicals; Pain -- Pathophysiology -- Periodicals; Pain -- Physiological aspects -- Periodicals; 616.0472
• DOI: 10.1177/17448069211050246
• Languages: English
• ISSNs: 1744-8069

Abstract

Migraine is the second most prevalent disorder in the world; yet, its underlying mechanisms are still poorly understood. Cumulative studies have revealed pivotal roles of cerebral cortex in the initiation, propagation, and termination of migraine attacks as well as the interictal phase. Investigation of basic mechanisms of the cortex in migraine not only brings insight into the underlying pathophysiology but also provides the basis for designing novel treatments. We aim to summarize the current research literatures and give a brief overview of the cortex and its role in migraine, including the basic structure and function; structural, functional, and biochemical neuroimaging; migraine-related genes; and theories related to cortex in migraine pathophysiology. We propose that long-term plasticity of synaptic transmission in the cortex encodes migraine.