Gynecologic Cancer InterGroup (GCIG) Consensus Review for Clear Cell Carcinoma of the Ovary. (1st November 2014)

• Record Type: Journal Article
• Authors: Okamoto, Aikou; Glasspool, Rosalind M.; Mabuchi, Seiji; Matsumura, Noriomi; Nomura, Hiroyuki; Itamochi, Hiroaki; Takano, Masashi; Takano, Tadao; Susumu, Nobuyuki; Aoki, Daisuke; Konishi, Ikuo; Covens, Alan; Ledermann, Jonathan; Mezzazanica, Delia; Steer, Christopher; Millan, David; McNeish, Iain A.; Pfisterer, Jacobus; Kang, Sokbom; Gladieff, Laurence; Bryce, Jane; Oza, Amit
• Is Part Of: International journal of gynecological cancer. Volume 24(2014)Supplement 3
• Page Start: S20
• Page End: S25
• Publication Date: 2014-11-01
• Subjects: Clear cell carcinoma of the ovary (CCC) -- Deep venous thrombosis -- Glycogen -- Hepatocyte nuclear factor-1ß -- WT1 -- Pulmonary embolism -- Ethnics -- ARID1A -- PIK3CA -- PPM1D -- PPP2R1A -- KRAS -- Cytoreductive surgery -- Paclitaxel -- Platinum -- Irinotecan hydrochloride -- Cisplatin -- PI3K/AKT/mTOR; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1097/IGC.0000000000000289
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Abstract: Clear cell carcinoma of the ovary (CCC) is a histologic subtype of epithelial ovarian cancer with a distinct clinical behavior. There are marked geographic differences in the prevalence of CCC. The CCC is more likely to be detected at an early stage than high-grade serous cancers, and when confined within the ovary, the prognosis is good. However, advanced disease is associated with a very poor prognosis and resistance to standard treatment. Cytoreductive surgery should be performed for patients with stage II, III, or IV disease. An international phase III study to compare irinotecan/cisplatin and paclitaxel/carboplatin as adjuvant chemotherapy for stage IIV CCC has completed enrollment (GCIG/JGOG3017). Considering the frequent PIK3CA mutation in CCC, dual inhibitors targeting PI3K, AKT in the mTOR pathway, are promising. Performing these trials and generating the evidence will require considerable international collaboration.