Circulating integrin α4β7+ CD4 T cells are enriched for proliferative transcriptional programs in HIV infection. Issue 17 (26th July 2021)

• Record Type: Journal Article
• Authors: Lakshmanappa, Yashavanth S.; Roh, Jamin W.; Rane, Niharika N.; Dinasarapu, Ashok R.; Tran, Daphne D.; Velu, Vijayakumar; Sheth, Anandi N.; Ofotokun, Igho; Amara, Rama R.; Kelley, Colleen F.; Waetjen, Elaine; Iyer, Smita S.
• Is Part Of: FEBS letters. Volume 595:Issue 17(2021)
• Page Start: 2257
• Page End: 2270
• Publication Date: 2021-07-26
• Subjects: HIV -- integrin α4 -- rectal mucosa -- susceptibility -- tissue resident memory T cells -- β7 CD4 T cells; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.14163
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : HIV preferentially infects α4 β7 + CD4 T cells, forming latent reservoirs that contribute to HIV persistence during antiretroviral therapy. However, the properties of α4 β7 + CD4 T cells in blood and mucosal compartments remain understudied. Employing two distinct models of HIV infection, HIV‐infected humans and simian–human immunodeficiency virus (SHIV)‐infected rhesus macaques, we show that α4 β7 + CD4 T cells in blood are enriched for genes regulating cell cycle progression and cellular metabolism. Unlike their circulating counterparts, rectal α4 β7 + CD4 T cells exhibited a core tissue‐residency gene expression program. These features were conserved across primate species, indicating that the environment influences memory T‐cell transcriptional networks. Our findings provide an important molecular foundation for understanding the role of α4 β7 in HIV infection. Abstract :