Brain oxygen extraction fraction mapping in patients with multiple sclerosis. Issue 2 (February 2022)

• Record Type: Journal Article
• Authors: Cho, Junghun; Nguyen, Thanh D; Huang, Weiyuan; Sweeney, Elizabeth M; Luo, Xianfu; Kovanlikaya, Ilhami; Zhang, Shun; Gillen, Kelly M; Spincemaille, Pascal; Gupta, Ajay; Gauthier, Susan A; Wang, Yi
• Is Part Of: Journal of cerebral blood flow & metabolism. Volume 42:Issue 2(2022)
• Page Start: 338
• Page End: 348
• Publication Date: 2022-02
• Subjects: Oxygen extraction fraction -- multiple sclerosis -- quantitative susceptibility mapping -- quantitative blood oxygenation level dependent magnitude -- QSM+qBOLD; Cerebral circulation -- Periodicals; Brain -- Metabolism -- Periodicals; Brain -- Blood-vessels -- Periodicals; Cerebrovascular disease -- Periodicals; 612.824
• DOI: 10.1177/0271678X211048031
• Languages: English
• ISSNs: 0271-678X

Abstract

We aimed to demonstrate the feasibility of whole brain oxygen extraction fraction (OEF) mapping for measuring lesion specific and regional OEF abnormalities in multiple sclerosis (MS) patients. In 22 MS patients and 11 healthy controls (HC), OEF and neural tissue susceptibility (χ n ) maps were computed from MRI multi-echo gradient echo data. In MS patients, 80 chronic active lesions with hyperintense rim on quantitative susceptibility mapping were identified, and the mean OEF andχ n within the rim and core were compared using linear mixed-effect model analysis. The rim showed higher OEF andχ n than the core: relative to their adjacent normal appearing white matter, OEF contrast = −6.6 ± 7.0% vs. −9.8 ± 7.8% (p < 0.001) andχ n contrast = 33.9 ± 20.3 ppb vs. 25.7 ± 20.5 ppb (p = 0.017). Between MS and HC, OEF andχ n were compared using a linear regression model in subject-based regions of interest. In the whole brain, compared to HC, MS had lower OEF, 30.4 ± 3.3% vs. 21.4 ± 4.4% (p < 0.001), and higherχ n, −23.7 ± 7.0 ppb vs. −11.3 ± 7.7 ppb (p = 0.018). Our feasibility study suggests that OEF may serve as a useful quantitative marker of tissue oxygen utilization in MS.