New insights into the diagnosis and management of bone health in premature ovarian insufficiency. (3rd September 2021)

• Record Type: Journal Article
• Authors: Nguyen, H. H.; Milat, F.; Vincent, A. J.
• Is Part Of: Climacteric. Volume 24:Number 5(2021)
• Page Start: 481
• Page End: 490
• Publication Date: 2021-09-03
• Subjects: Premature ovarian insufficiency -- premature menopause -- osteoporosis -- fractures -- dual-energy X-ray absorptiometry -- bone mineral density -- muscle; Menopause -- Periodicals; Menopause -- Hormone therapy -- Periodicals; Menopause -- Periodicals; Estrogen Replacement Therapy -- Periodicals; Gynecology -- Periodicals; Societies, Medical -- Periodicals; 612.665
• DOI: 10.1080/13697137.2021.1917539
• Languages: English
• ISSNs: 1369-7137

Abstract

Abstract: Premature ovarian insufficiency (POI), defined as a loss of ovarian function before the age of 40 years, is a life-changing diagnosis that has numerous long-term consequences. Musculoskeletal complications, including osteoporosis and fractures, are a key concern for women with POI. The risk of bone loss is influenced by the underlying etiology of POI, and the degree and duration of estrogen deficiency. A decline in muscle mass as a result of estrogen and androgen deficiency may contribute to skeletal fragility, but has not been examined in women with POI. This article aims to review musculoskeletal health in POI; summarize the traditional and novel modalities available to screen for skeletal fragility and muscle dysfunction; and provide updated evidence for available management strategies.