Bayesian Causal Mediation Analysis with Latent Mediators and Survival Outcome. Issue 5 (3rd September 2021)
- Record Type:
- Journal Article
- Title:
- Bayesian Causal Mediation Analysis with Latent Mediators and Survival Outcome. Issue 5 (3rd September 2021)
- Main Title:
- Bayesian Causal Mediation Analysis with Latent Mediators and Survival Outcome
- Authors:
- Sun, Rongqian
Zhou, Xiaoxiao
Song, Xinyuan - Abstract:
- ABSTRACT: This study develops a joint modeling approach that incorporates latent traits into causal mediation analysis with multiple mediators and a survival outcome. A linear structural equation model is used to characterize the latent mediators with several highly correlated observable surrogates and depicts the relationships among multiple parallel or causally ordered mediators and the exposure. A proportional hazards model is used to derive the path-specific causal effects on the scale of hazard ratio under the counterfactual framework with a set of sequential ignorability assumptions. A Bayesian approach with Markov chain Monte Carlo algorithm is developed to perform efficient estimation of the causal effects. Posterior propriety theory is established for the proportional hazards model with latent variables. Empirical performance of the proposed method is verified through simulation studies. The proposed model is then applied to a study on the Alzheimer's Disease Neuroimaging Initiative dataset to investigate the causal effects of APOE- ε 4 allele on the disease progression, either directly or through potential mediators, such as hippocampus atrophy, ventricle expansion, and cognitive impairment.
- Is Part Of:
- Structural equation modeling. Volume 28:Issue 5(2021)
- Journal:
- Structural equation modeling
- Issue:
- Volume 28:Issue 5(2021)
- Issue Display:
- Volume 28, Issue 5 (2021)
- Year:
- 2021
- Volume:
- 28
- Issue:
- 5
- Issue Sort Value:
- 2021-0028-0005-0000
- Page Start:
- 778
- Page End:
- 790
- Publication Date:
- 2021-09-03
- Subjects:
- Bayesian method -- causal mediation -- latent variable -- posterior propriety -- survival outcome
Multivariate analysis -- Periodicals
Social sciences -- Statistical methods -- Periodicals
519.535 - Journal URLs:
- http://www.informaworld.com/smpp/title~db=all~content=t775653699 ↗
http://www.tandfonline.com/toc/hsem20/current ↗
http://www.tandfonline.com/ ↗
http://www.leaonline.com/loi/sem ↗ - DOI:
- 10.1080/10705511.2020.1863154 ↗
- Languages:
- English
- ISSNs:
- 1070-5511
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8477.210000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 18657.xml