The Effect of Infant Formulas With 4 or 8 g/L GOS/FOS on Growth, Gastrointestinal Symptoms, and Behavioral Patterns: A Prospective Cohort Study. (September 2021)

• Record Type: Journal Article
• Authors: Tonon, Karina Merini; Tomé, Thaís Moreno; Mosquera, Elaine Martins Bento; Perina, Natália Pratis; Lazarini, Tamara
• Is Part Of: Global pediatric health. Volume 8(2021)
• Publication Date: 2021-09
• Subjects: infant formula -- prebiotics -- stool consistency -- stool frequency -- weight gain; Pediatrics -- Periodicals; Children -- Health and hygiene -- Periodicals; 618.92
• DOI: 10.1177/2333794X211044115
• Languages: English
• ISSNs: 2333-794X

Abstract

There is a lack of studies investigating the clinical benefits of prebiotic-supplemented infant formula. In this study, healthy infants that started, on medical recommendation, artificial feeding with one of 2 infant formulas containing 4 g/L of GOS/FOS (9:1) (IF4 group; n = 60) or 8 g/L of GOS/FOS (9:1) (IF8 group; n = 60) were followed for 30 days to the evaluation of growth and gastrointestinal symptoms. Exclusively breastfed infants (EBF; n = 60) were followed up as a reference. Both infant formulas supported adequate weight gain, however, IF4 formula promotes growth more similar to breastfed infants. There was no additional benefit of a dose higher than 4 g/L of GOS/FOS on gastrointestinal symptoms.