Associations of telomere length at birth with predicted atherosclerotic lesions and cardiovascular disease risk factors in midlife: A 40-year longitudinal study. (September 2021)

• Record Type: Journal Article
• Authors: Niu, Zhongzheng; Wen, Xiaozhong; Buka, Stephen L.; Wang, Meng; Tian, Lili; Loucks, Eric B.; Kubzansky, Laura D.; Mu, Lina
• Is Part Of: Atherosclerosis. Volume 333(2021)
• Page Start: 67
• Page End: 74
• Publication Date: 2021-09
• Subjects: Telomere length -- Atherosclerosis -- Cardiovascular disease -- PDAY -- Longitudinal study -- Life-course; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2021.08.013
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background and aims: Adult telomere length (TL) is substantially determined by birth TL, but associations of birth TL with cardiovascular disease (CVD) are unknown. Methods: We included 144 adult offspring born in 1959–1966 from the Collaborative Perinatal Project, a US birth cohort. Birth TL was measured from banked cord blood with quantitative polymerase chain reaction. Atherosclerotic lesions were predicted by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) score that was based on blood pressure, lipids, hemoglobin A1c, and body weight at the midlife follow-up in 2003–2008 (average age: 42 years). Information on midlife CVD risk factors including the age at first diagnoses of hypertension, hypercholesterolemia, and diabetes was also collected. We used linear and logistic regression models to analyze associations of birth TL with the continuous PDAY score and categorical CVD risk factors, respectively, adjusting for prenatal confounders. Results: At midlife follow-up, 31.2% and 18.7% of participants had ever been diagnosed with hypercholesterolemia and hypertension, respectively, and 8.3% met the criteria for metabolic syndrome. Short birth TL (Quartile 1, Q1) was associated with a higher PDAY score (adjusted β : 1.78, 95% CI: 0.31, 3.25), increased odds of hypercholesterolemia (adjusted odds ratio [OR]: 3.23, 95% CI: 1.28, 8.18) and the presence of any cardiometabolic abnormalities (adjusted OR: 2.54, 95% CI: 1.00, 6.48) as compared to longer birth TL (Q2-Q4) after adjusting for prenatal confounders. Conclusions: People born with short TL may be at increased risk of predicted midlife atherosclerotic lesions and hypercholesterolemia. Future studies with larger sample sizes and CVD morbidities are warranted to replicate our findings. Graphical abstract: Image 1 Highlights: As a marker of cellular aging, adult telomere length (TL) is determined by birth TL. Adult TL has been associated with cardiovascular disease. We investigated the unknown association of birth TL with cardiovascular disease. Short birth TL was prospectively associated with midlife atherosclerotic lesions. Short birth TL was also associated with midlife risk of hypercholesterolemia.