Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (25th August 2021)

• Record Type: Journal Article
• Authors: Zhang, Tianqing; He, Qi; Liu, Yao; Chen, Zhenrong; Hu, Hengjing
• Other Names: Silva Denise Brentan Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2021(2021)
• Publication Date: 2021-08-25
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2021/4471944
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Background . Diabetes is a major public health concern. In addition, there is some evidence to support curcumin as part of a diabetes treatment program. Methods . Data from randomized controlled trials were obtained to assess the effects of curcumin versus placebo or western medicine in patients with type 2 diabetes mellitus (T2DM). The study's registration number is CRD42018089528. The primary outcomes included homeostasis model assessment-insulin resistance (HOMA-IR), glycosylated hemoglobin (HbAlc), total cholesterol (TC), and triglyceride (TG). Results . Four trials involving 453 patients were included. The HOMA-IR of curcumin group is lower in Asia (WMD: −2.41, 95% CI: −4.44 to −0.39, P = 0.02 ) and the Middle East subgroups (WMD: −0.60, 95% CI: −0.74 to −0.46, P < 0.00001 ). The HbAlc in the curcumin group is lower than that in the control group (WMD: −0.69; 95% CI: −0.91, −0.48; P < 0.0001 ). The TC and TG levels of the curcumin group are lower in the Asia subgroup (TC: WMD: −23.45, 95% CI: −40.04 to −6.84, P = 0.006 ; TG: WMD: −54.14, 95% CI: −95.71 to −12.57, P = 0.01 ), while in the Middle East the difference was of not statistically significant (TC: WMD: 22.91, 95% CI: −16.94 to 62.75, P = 0.26 ; TG: WMD: −4.56, 95% CI: −19.28 to 10.16, P = 0.54 ). Conclusion . Based on the current evidence, curcumin may assist in improving the insulin resistance, glycemic control, and decreased TG and TC in patients with T2DM.