Kochia scoparia Saponin Momordin Ic Modulates HaCaT Cell Proliferation and Apoptosis via the Wnt/β-Catenin Pathway. (17th July 2021)

• Record Type: Journal Article
• Authors: Luo, Meijunzi; Zeng, Bijun; Wang, Haizhen; Yang, Zhibo; Peng, Youhua; Zhang, Yujin; Wang, Chang
• Other Names: Wall Medrano Abraham Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2021(2021)
• Publication Date: 2021-07-17
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2021/5522164
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Psoriasis is a chronic, recurrent, immunoinflammatory disease. For a long period, Traditional Chinese Medicine (TCM) is considered a reliable alternative therapy for patients with psoriasis. Fructus Kochiae (or Kochia scoparia ) and its principle saponin, Momordin Ic, have been reported to protect against inflammation. Herein, we demonstrated that Momordin Ic could inhibit HaCaT cell proliferation and enhance cell apoptosis. In the meantime, Momordin Ic alters Wnt/ β -catenin pathway activation by affecting β -catenin nuclear distribution. The Wnt/ β -catenin signaling activator LiCl partially reversed the effects of Momordin Ic on HaCaT phenotypes and the Wnt/ β -catenin pathway factors. Altogether, we demonstrate the inhibitory effects of Momordin Ic, one of the major saponin constituents of Fructus Kochiae, on HaCaT cell proliferation and Momordin Ic-induced alteration within the Wnt/ β -catenin pathway. Momordin Ic might act on HaCaT cells by modulating the Wnt/ β -catenin pathway.