Cytotoxic steroidal glycosides from Polygonatum odoratum (Mill.) Druce. (November 2021)

• Record Type: Journal Article
• Authors: Zhou, Di; Feng, Yuan; Li, Wei; Liu, Bo; Liu, Xin; Sun, Lu; Koike, Kazuo; Chen, Gang; Li, Ning
• Is Part Of: Phytochemistry. Volume 191(2021)
• Publication Date: 2021-11
• Subjects: Polygonatum odoratum (Mill.) druce (asparagaceae) -- Steroidal glycosides -- Cancer cell lines -- Cytotoxicities; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2021.112906
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Twenty-five steroidal glycosides including eight undescribed compounds which were named as polygonatumosides H–O, were isolated from the 70 % EtOH extract of rhizomes of Polygonatum odoratum (Mill.) Druce (Asparagaceae). Their structures were elucidated by extensive spectroscopic analyses and chemical methods. The isolated compounds were evaluated cytotoxicity against three human cancer cell lines: human non-small cell lung cancer (A549), human epithelial colorectal adenocarcinoma (Caco2), and human hepatocellular carcinoma (HepG2) cells. Five compounds showed cytotoxicity against these cell lines with IC50 values in the range of 1.7–30.8 μM. Graphical abstract: Eight undescribed and 17 known glycosides were identified from Polygonatum odoratum and their activities were evaluated against three cancer cell lines. Image 1 Highlights: Eight undescribed and 17 known glycosides were identified from Polygonatum odoratum. Three cancer cell lines were conducted to evaluate their activities. Inhibitory effects of five compounds were reported.