Janohigenins: Long-chain anacardic acid derivatives with neuroprotective activity from Ophiopogon japonicus seeds. (November 2021)

• Record Type: Journal Article
• Authors: Ohta, Shinji; Takeda, Manami; Ohta, Emi; Nehira, Tatsuo; Ômura, Hisashi; Uy, Mylene M.; Ishihara, Yasuhiro
• Is Part Of: Phytochemistry. Volume 191(2021)
• Publication Date: 2021-11
• Subjects: Ophiopogon japonicus -- Asparagaceae -- Seed -- Anacardic acid derivatives -- Neuroprotective activity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2021.112904
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Eight hitherto undescribed long-chain anacardic acid derivatives, janohigenins, were isolated from the endosperm of Ophiopogon japonicus seed, and their structures were elucidated employing spectroscopic and chemical methods. The neuroprotective activity of the isolated compounds was evaluated against rotenone-induced cellular damage in SH-SY5Y human neuroblastoma cells. Janohigenins exhibited noticeable neuroprotection at 1 μM. Graphical abstract: Eight undescribed long-chain anacardic acid derivatives were isolated from the endosperm of Ophiopogon japonicus seed and their structures were determined on the basis of their spectroscopy. Their neuroprotective activity against rotenone-induced cellular damage in SH-SY5Y human neuroblastoma cells was evaluated. Image 1 Highlights: Eight long-chain anacardic acid derivatives were isolated from Ophiopogon japonicus seeds. Their structures were elucidated based on the spectroscopic data. Janohigenins exhibit neuroprotective activity for rotenone-induced cellular damage. A possible biosynthetic pathway of janohigenins was proposed.