Polyenvironmental and polygenic risk scores and the emergence of psychotic experiences in adolescents. (October 2021)

• Record Type: Journal Article
• Authors: Navarro, Gabrielle de Oliveira S.V.; Fonseca, Laís; Talarico, Fernanda; Spíndola, Letícia; Santoro, Marcos L.; Ota, Vanessa K.; Cogo-Moreira, Hugo; Mari, Jair; Rohde, Luis A.; Miguel, Eurípedes C.; Bressan, Rodrigo A.; Pan, Pedro M.; Gadelha, Ary; Belangero, Sintia I.
• Is Part Of: Journal of psychiatric research. Volume 142(2021)
• Page Start: 384
• Page End: 388
• Publication Date: 2021-10
• Subjects: Psychotic experiences -- Environmental -- Polygenic risk score -- Polyenvironmental risk score -- PERS -- PRS; Psychiatry -- Periodicals; Mental Disorders -- Periodicals; Maladies mentales -- Périodiques; Psychiatry; Electronic journals; Periodicals; 616.89005
• DOI: 10.1016/j.jpsychires.2021.07.057
• Languages: English
• ISSNs: 0022-3956

Abstract

Abstract: Psychotic experiences (PE) are forms of hallucinations and delusions neither reaching the intensity and functional impairment required to be regarded as full psychotic symptoms nor a psychotic disorder. Here we investigated the ability to predict PE using multiple models (regressions, mediation and moderation) using polygenic risk score for psychotic experiences (PE-PRS), polygenic risk score for schizophrenia (SCZ-PRS), and polyenvironmental risk score (PERS) in youth from a Brazilian sample. The scores were not able to predict outcome, either when both scores were combined (PERS + PE-PRS and PERS + SCZ-PRS) or separately. Our results show that there is no association between PE and PRS or PERS among adolescents in our Brazilian sample. The lack of association may be a result of the absence of better representativeness regarding genetic and environmental factors of our population.