Chimonanthus nitens Oliv. essential oil mitigates lipopolysaccharide-induced acute lung injury in rats. (October 2021)

• Record Type: Journal Article
• Authors: Wan, Min; Yao, Yu-fei; Wu, Wei; Fu, Wang-wei; Wu, Rui-ting; Li, Wen-juan
• Is Part Of: Food and chemical toxicology. Volume 156(2021)
• Publication Date: 2021-10
• Subjects: Chimonanthus nitens Oliv. essential oil -- Acute lung injury -- Inflammation -- Antioxidant defense -- Short-chain fatty acids; LPS lipopolysaccharide -- ALI acute lung injury -- SCFAs short-chain fatty acids -- CEO Chimonanthus nitens Oliv. essential oil -- GC-MS gas chromatography-mass spectrometry -- DMSO dimethyl sulfoxide -- DEX dexamethasone sodium phosphate Injection -- WBC white blood cell -- H&E hematoxylin-eosin staining -- IL interleukin -- FID flame ionization detector -- LSD Least Significant Difference; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2021.112445
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: This study aimed to evaluate the effect of Chimonanthus nitens Oliv. essential oil (named CEO) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in rats. In the present study, 21 compounds were characterized in CEO by gas chromatography-mass spectrometry analysis. Furthermore, animal data suggested that CEO could protect rats against ALI, as evidence by increasing white blood cell count, reducing immune organ index and improving lung histopathological changes in rats subjected to LPS. Reduction of the levels of IL-1β was also shown during CEO-triggering lung protection in rats. Meanwhile, these protective effects of CEO were accompanied by the attenuation of lipid oxidation, and elevation of antioxidant enzymes, suggesting that enhancement of antioxidant defense was linked to its lung protection. Moreover, a combination with CEO and LPS significantly elevated short-chain fatty acids (SCFAs) compared with LPS alone via increasing propionic, i-butyric, butyric and i-valeric acid on LPS-induced ALI in rats. Therefore, our findings indicated that CEO could alleviate LPS-caused ALI in rats by controlling aberrant inflammation, correcting the redox system, and modulating SCFAs in rats. Graphical abstract: Image 1 Highlights: Chimonanthus nitens Oliv. essential oil possessed 21 compounds by GC-MS analysis. Chimonanthus nitens Oliv. essential oil could protect ALI by controlling aberrant inflammatory response. Chimonanthus nitens Oliv. essential oil enhanced antioxidant defense, which was linked to its lung protection. Chimonanthus nitens Oliv. essential oil could significantly improve short-chain fatty acids in cecal contents of rats.