US LI-RADS Visualization Score: Interobserver Variability and Association With Cause of Liver Disease, Sex, and Body Mass Index. Issue 1 (February 2022)

• Record Type: Journal Article
• Authors: Kiri, Lauren; Abdolell, Mohamed; Costa, Andreu F.; Keough, Valerie; Rowe, Judy; Butt, Robinette; Clarke, Sharon E.
• Other Names: Seely Jean Morag guest-editor.
• Is Part Of: Canadian Association of Radiologists journal. Volume 73:Issue 1(2022)
• Page Start: 68
• Page End: 74
• Publication Date: 2022-02
• Subjects: ultrasound -- hepatocellular carcinoma -- surveillance -- observer variation -- cirrhosis -- US LI-RADS; Radiology, Medical -- Periodicals; Radiology, Medical -- Canada -- Periodicals; 616.0757
• DOI: 10.1177/08465371211012104
• Languages: English
• ISSNs: 0846-5371

Abstract

Objectives: To evaluate the interobserver agreement between radiologists using the Ultrasound Liver Reporting And Data System (US LI-RADS) visualization score and assess association between visualization score and cause of liver disease, sex, and body mass index (BMI). Methods: This retrospective, single institution, cross-sectional study evaluated 237 consecutive hepatocellular carcinoma surveillance US examinations between March 4, 2017 and September 4, 2017. Five abdominal radiologists independently assigned a US LI-RADS visualization score (A, no or minimal limitations; B, moderate limitations; C, severe limitations). Interobserver agreement was assessed with a weighted Kappa statistic. Association between US visualization score (A vs B or C) and cause of liver disease, sex, and BMI (< or ≥ 25 kg/m 2 ) was evaluated using univariate and multivariate analyses. Results: The average weighted Kappa statistic for all raters was 0.51. A score of either B or C was assigned by the majority of radiologists in 148/237 cases and was significantly associated with cause of liver disease ( P = 0.014) and elevated BMI ( P < 0.001). Subjects with viral liver disease were 3.32 times (95% CI: 1.44-8.38) more likely to have a score of A than those with non-alcoholic steatohepatitis ( P = 0.007). The adjusted odds ratio of visualization score A was 0.249 (95% CI: 0.13-0.48) among those whose BMI was ≥25 kg/m 2 vs. BMI < 25 kg/m 2 . Conclusion: Interobserver agreement between radiologists using US LI-RADS score was moderate. The majority of US examinations were scored as having moderate or severe limitations, and this was significantly associated with non-alcoholic steatohepatitis and increased BMI.