Bacillus amyloliquefaciens B10 inhibits aflatoxin B1-induced cecal inflammation in mice by regulating their intestinal flora. (October 2021)

• Record Type: Journal Article
• Authors: Chen, Jia; Lv, Zhiming; Cheng, Ziyang; Wang, Tiancheng; Li, Peng; Wu, Aibo; Nepovimova, Eugenie; Long, Miao; Wu, Wenda; Kuca, Kamil
• Is Part Of: Food and chemical toxicology. Volume 156(2021)
• Publication Date: 2021-10
• Subjects: Aflatoxin B1 -- Bacillus amyloliquefaciens B10 -- Intestinal flora -- Tight junction protein; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2021.112438
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Aflatoxin B1 is a mycotoxin that widely exists in feed and has a great impact on human and animal health. This study aimed to examine whether Bacillus amyloliquefaciens B10 protected against aflatoxin B1-induced cecal inflammation in mice. It was found that Bacillus amyloliquefaciens B10 could significantly improve the effects of AFB1 on body weight and intestinal inflammation of mice and enhance the expression of tight-junction protein. Compared with the CON group, the combination of AFB1 and B10 significantly increased the abundance of Actinobacteria and Bacilli in a collaborative manner, and significantly reduced the abundance of Ruminococcae, Lactobacillaceae and Clostridia . Meanwhile, the results showed that the abundance of Bacterides and Bacterdia in AFB1 + B10 group was significantly lower than that of AFB1 group, and the Firmicutes increased significantly. Bacillus amyloliquefaciens B10 can be used as a feed additive and alleviate cecal inflammation induced by AFB1 in mice by regulating intestinal flora. Graphical abstract: Image 1 Highlights: ● Aflatoxin B1 alters intestinal flora and induces intestinal inflammation in mice. ● Bacillus amyloliquefaciens B10 can alleviate the effect that AFB1 has on the weight of the mice. ● Bacillus amyloliquefaciens B10 can inhibit AFB1-induced cecal inflammation in mice.