Thirteen undescribed diterpenoid quinones derived from the rhizomes of Salvia miltiorrhiza and their anti-tumor activities. (November 2021)

• Record Type: Journal Article
• Authors: Yin, Zhao-Kun; Liu, Zhao-Zhen; Yuan, Xiang; Feng, Zi-Ming; Jiang, Jian-Shuang; Zhang, Xu; Zhang, Pei-Cheng; Yang, Ya-Nan
• Is Part Of: Phytochemistry. Volume 191(2021)
• Publication Date: 2021-11
• Subjects: Salvia miltiorrhiza -- Lamiaceae -- Diterpenoid quinones -- Absolute configurations -- Anti-tumor activities; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2021.112902
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Thirteen undescribed diterpenoid quinones were isolated from the dried roots of Salvia miltiorrhiza . Their structures were determined by extensive analysis, including NMR, HRESIMS, and IR. Their absolute configurations were determined by X-ray diffraction, calculated and experimental circular dichroism spectroscopy, and optical rotation. In the evaluation of bioactivities, salviadionether obviously inhibited the proliferation of HCT-116 cells. R -(+)-salmiltiorin E and R -(+)-grandifolia D both showed inhibitory activities on a variety of tumor cells. Salvianone ester A showed strong cytotoxicity to tumor-repopulating cells (TRCs) with an IC50 value of 2.19 μ M. Graphical abstract: Image 1 Highlights: Thirteen undescribed diterpenoid quinones were isolated from the roots of Salvia miltiorrhiza. Salviadionether, R -(+)-salmiltiorin E and R -(+)-grandifolia D showed obvious anti-cancer activities in vitro . Salvianone ester A showed significant cytotoxicity to A375 TRCs (IC50 = 2.19 μ M). Their structures were elucidated using various spectroscopy data and chemical evidence.