Devastating effects of chemotherapy: deafness and acute renal failure in a patient with epithelial ovarian cancer. (1st January 2006)

• Record Type: Journal Article
• Authors: Ozguroglu, M.; Sari, O.; Turna, H.
• Is Part Of: International journal of gynecological cancer. Volume 16(2006)Supplement 1
• Page Start: 394
• Page End: 396
• Publication Date: 2006-01-01
• Subjects: acute renal failure -- carboplatin -- loss of hearing -- paclitaxel; Generative organs, Female -- Cancer -- Periodicals; 616.99465
• DOI: 10.1136/ijgc-00009577-200602001-00072
• Languages: English
• ISSNs: 1048-891X

Abstract

Abstract : Paclitaxel and platinum combination is the standard chemotherapy regimen for patients with advanced epithelial ovarian cancer. The dose-limiting toxicity effects of this combination are myelosuppression and neuropathy. Herein, we report a case of a 71-year-old female with advanced epithelial ovarian cancer who developed bilateral total loss of hearing and acute renal failure related with paclitaxel- and carboplatin-based chemotherapy. Acute renal failure accompanied by complete loss of hearing in patients treated with carboplatin and paclitaxel combination has not been previously reported. This uncommon adverse effect of carboplatin and paclitaxel combination was discussed, and all the literature in English related with the toxicity of paclitaxel and carboplatin were reviewed.