Plasma-activated thermosensitive biogel as an exogenous ROS carrier for post-surgical treatment of cancer. (September 2021)

• Record Type: Journal Article
• Authors: Zhang, Hao; Xu, Shengduo; Zhang, Jishen; Wang, Zifeng; Liu, Dingxin; Guo, Li; Cheng, Cheng; Cheng, Yilong; Xu, Dehui; Kong, Michael G.; Rong, Mingzhe; Chu, Paul K.
• Is Part Of: Biomaterials. Volume 276(2021)
• Publication Date: 2021-09
• Subjects: Post-operative tumor treatment -- Surface discharge plasma -- Reactive oxygen species -- Plasma-activated biogel; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2021.121057
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Post-surgical residual tumor cells are the primary cause of relapse and progression of cancer but unfortunately, there are limited therapeutic options. In this work, a fillable plasma-activated biogel is produced on a thermosensitive biogel [(Poly-DL-lactide)-(poly-ethylene glycol)-(poly-DL-lactide), PLEL] with the aid of a discharge plasma for local post-operative treatment of cancer. In vivo data show that the plasma-activated PLEL biogel (PAPB) eliminates residual tumor tissues after removal surgery and also inhibits in situ recurrence while showing no evident systemic toxicity. Moreover, the PAPB possesses excellent storage capability, allows for slow release of plasma-generated reactive oxygen species (ROS), and exhibits good ROS-mediated anticancer effects in vitro . Our results reveal that the novel plasma-activated biogel is an effective therapeutic agent for local post-operative treatment of cancer.