Albumin–Globulin Ratio Is an Independent Determinant of 28-Day Mortality in Patients with Critical Illness. (26th August 2021)

• Record Type: Journal Article
• Authors: Liu, Bin; Xiao, Kun; Yan, Peng; Sun, Tianyu; Wang, Jiang; Xie, Fei; Mo, Guoxin; Xie, Lixin
• Other Names: Himmerich Hubertus Academic Editor.
• Is Part Of: Disease markers. Volume 2021(2021)
• Publication Date: 2021-08-26
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2021/9965124
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Background . Critical illness in the intensive care unit (ICU) has been a global health priority. Systemic nutritional status has turned out to be related to the prognosis of critically ill patients. The albumin-globulin ratio (AGR) has been reported to be a novel prognostic factor of many diseases. This study is aimed at investigating whether the AGR could predict the mortality risk in critically ill patients. Methods . We enrolled 582 adult patients admitted to the respiratory intensive care unit (RICU). We collected the clinical and laboratory data. X-tile software was used to determine the optimal cut-off values for the AGR. Patients were divided into three groups according to the AGR (low AGR group with AGR < 0.8, medium AGR group with AGR ranging from 0.8 to 1.1, and high AGR group with AGR > 1.1 ). Kaplan-Meier analysis was used for survival analysis. A Cox proportional hazard model was applied to the univariate and multivariate analyses for the potential predictors associated with survival. Results . Our present study showed that the AGR was related to the 28-day survival of critically ill patients in the RICU. The rate of pneumonia in the low AGR group was significantly higher than that in the other groups. Patients with a lower AGR present an increased risk of 28-day mortality compared to patients with a higher AGR. Cox regression analysis showed that the AGR might be an independent predictor of prognosis to 28-day survival in critically ill patients in the RICU. Medium and high AGR values remained independently associated with better 28-day survival than low AGR values (HR: 0.484 (0.263-0.892) (p = 0.02 ); HR: 0.332 (0.166-0.665) (p = 0.002 )). Conclusion . The AGR might be an independent predictor of prognosis in critically ill patients.