Cover Feature: Genetic Encoding of a Bioconjugation Handle for [2+2+2] Cycloaddition Reactions (ChemBioChem 3/2020). (21st January 2020)

• Record Type: Journal Article
• Authors: Travis, Christopher R.; King, Elizabeth A.; Gaunt, Gillian H.; Young, Douglas D.
• Is Part Of: Chembiochem. Volume 21:Number 3(2020)
• Page Start: 280
• Page End: 280
• Publication Date: 2020-01-21
• Subjects: alkynes -- bioconjugation -- cycloaddition -- unnatural amino acids; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.202000012
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The development of novel bioconjugation strategies is useful for various therapeutic and diagnostic applications. This work describes the synthesis and genetic encoding of an unnatural amino acid that serves as a functional handle for numerous bioconjugations. In particular it can be employed in bioorthogonal [2+2+2] cycloaddition reactions to either conjugate a small‐molecule probe/drug or to immobilize a protein on a surface. More information can be found in the communication by D. D. Young et al. on page 310 in Issue 3, 2020 (DOI: 10.1002/cbic.201900391 ).