High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) Requiring Invasive Mechanical Ventilation. Issue 7 (10th June 2020)

• Record Type: Journal Article
• Authors: Simonnet, Arthur; Chetboun, Mikael; Poissy, Julien; Raverdy, Violeta; Noulette, Jerome; Duhamel, Alain; Labreuche, Julien; Mathieu, Daniel; Pattou, Francois; Jourdain, Merce
• Other Names: Caizzo Robert investigator.; Caplan Morgan investigator.; Cousin Nicolas investigator.; Duburcq Thibault investigator.; Durand Arthur investigator.; El kalioubie Ahmed investigator.; Favory Raphael investigator.; Garcia Bruno investigator.; Girardie Patrick investigator.; Goutay Julien investigator.; Houard Marion investigator.; Jaillette Emmanuelle investigator.; Kostuj Nicolas investigator.; Ledoux Geoffrey investigator.; Mathieu Daniel investigator.; Moreau Anne Sophie investigator.; Niles Christopher investigator.; Nseir Saad investigator.; Onimus Thierry investigator.; Parmentier Erika investigator.; Préau Sebastien investigator.; Robriquet Laurent investigator.; Rouze Anahita investigator.; Six Sophie investigator.; Verkindt Hélène investigator.
• Is Part Of: Obesity. Volume 28:Issue 7(2020)
• Page Start: 1195
• Page End: 1199
• Publication Date: 2020-06-10
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.22831
• Languages: English
• ISSNs: 1930-7381

Abstract

Abstract : Objective: The COVID‐19 pandemic is rapidly spreading worldwide, notably in Europe and North America where obesity is highly prevalent. The relation between obesity and severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has not been fully documented. Methods: This retrospective cohort study analyzed the relationship between clinical characteristics, including BMI, and the requirement for invasive mechanical ventilation (IMV) in 124 consecutive patients admitted in intensive care for SARS‐CoV‐2 in a single French center. Results: Obesity (BMI > 30) and severe obesity (BMI > 35) were present in 47.6% and 28.2% of cases, respectively. Overall, 85 patients (68.6%) required IMV. The proportion of patients who required IMV increased with BMI categories ( P < 0.01, χ 2 test for trend), and it was greatest in patients with BMI > 35 (85.7%). In multivariate logistic regression, the need for IMV was significantly associated with male sex ( P < 0.05) and BMI ( P < 0.05), independent of age, diabetes, and hypertension. The odds ratio for IMV in patients with BMI > 35 versus patients with BMI < 25 was 7.36 (1.63‐33.14; P = 0.02). Conclusions: The present study showed a high frequency of obesity among patients admitted in intensive care for SARS‐CoV‐2. Disease severity increased with BMI. Obesity is a risk factor for SARS‐CoV‐2 severity, requiring increased attention to preventive measures in susceptible individuals.