Rho GTPases: Regulation and roles in cancer cell biology. (1st October 2016)

• Record Type: Journal Article
• Authors: Haga, Raquel B.; Ridley, Anne J.
• Is Part Of: Small GTPases. Volume 7:Number 4(2016)
• Page Start: 207
• Page End: 221
• Publication Date: 2016-10-01
• Subjects: cancer progression -- cell migration -- Rho GTPases -- signal transduction; Guanosine triphosphatase -- Periodicals; Guanosine triphosphatase; Periodicals; 572.793
• DOI: 10.1080/21541248.2016.1232583
• Languages: English
• ISSNs: 2154-1256

Abstract

ABSTRACT: Rho GTPases are well known for their roles in regulating cell migration, and also contribute to a variety of other cellular responses. They are subdivided into 2 groups: typical and atypical. The typical Rho family members, including RhoA, Rac1 and Cdc42, cycle between an active GTP-bound and inactive GDP-bound conformation, and are regulated by GEFs, GAPs and GDIs, whereas atypical Rho family members have amino acid substitutions that alter their ability to interact with GTP/GDP and hence are regulated by different mechanisms. Both typical and atypical Rho GTPases contribute to cancer progression. In a few cancers, RhoA or Rac1 are mutated, but in most cancers expression levels and/or activity of Rho GTPases is altered. Rho GTPase signaling could therefore be therapeutically targeted in cancer treatment.