FOXC1-induced Gli2 activation: A non-canonical pathway contributing to stemness and anti-Hedgehog resistance in basal-like breast cancer. (3rd May 2016)
- Record Type:
- Journal Article
- Title:
- FOXC1-induced Gli2 activation: A non-canonical pathway contributing to stemness and anti-Hedgehog resistance in basal-like breast cancer. (3rd May 2016)
- Main Title:
- FOXC1-induced Gli2 activation: A non-canonical pathway contributing to stemness and anti-Hedgehog resistance in basal-like breast cancer
- Authors:
- Han, Bingchen
Qu, Ying
Yu-Rice, Yi
Johnson, Jeffrey
Cui, Xiaojiang - Abstract:
- ABSTRACT: The Forkhead box C1 (FOXC1) transcriptional factor is a critical biomarker for basal-like breast cancer (BLBC). We recently reported that FOXC1 promotes cancer stem cell properties in BLBC by activating Smoothened (SMO)-independent Hedgehog (Hh) signaling, suggesting a FOXC1-mediated mechanism for BLBC cell function and anti-Hh therapy resistance.
- Is Part Of:
- Molecular & cellular oncology. Volume 3:Number 3(2016)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 3:Number 3(2016)
- Issue Display:
- Volume 3, Issue 3 (2016)
- Year:
- 2016
- Volume:
- 3
- Issue:
- 3
- Issue Sort Value:
- 2016-0003-0003-0000
- Page Start:
- Page End:
- Publication Date:
- 2016-05-03
- Subjects:
- Basal-like breast cancer -- cancer stem cells -- FOXC1 -- GLI2 -- Hedgehog -- Smoothened
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2015.1131668 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 18609.xml