Breast milk oligosaccharides: effects of 2′-fucosyllactose and 6′-sialyllactose on the adhesion of Escherichia coli and Salmonella fyris to Caco-2 cells. (2nd September 2019)

• Record Type: Journal Article
• Authors: Facinelli, Bruna; Marini, Emanuela; Magi, Gloria; Zampini, Lucia; Santoro, Lucia; Catassi, Carlo; Monachesi, Chiara; Gabrielli, Orazio; Coppa, Giovanni V.
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 32:Number 17(2019)
• Page Start: 2950
• Page End: 2952
• Publication Date: 2019-09-02
• Subjects: Human milk oligosaccharides -- anti-adhesive effect -- 2′-fucosyllactose -- 6′-sialyllactose; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2018.1450864
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Background: It is well known that human milk oligosaccharides play an important role as prebiotics, anti-inflammatory, and anti-infective agents. In the last few years, several studies have been performed using specific oligosaccharides, such as 2′-fucosyllactose and 6′-sialylactose, to evaluate their biological functions. Objectives: The aim of the present study is to evaluate the anti-adhesive effect of the above oligosaccharides on Escherichia coli and Salmonella fyris . Methods: Adhesion experiments were performed in the presence of 2′-fucosyllactose and 6′-sialyllactose as potential inhibitors of Escherichia coli and Salmonella fyris adhesion to Caco-2 cells. The oligosaccharides were used at different concentrations and the adhesion experiments were performed in triplicate and repeated at least three times. Results: A significant reduction of Escherichia coli adhesion was observed in the presence of 2′-fucosyllactose and 6′-sialyllactose at the human milk concentration. On the contrary, no positive effects were observed in both oligosaccharides on Salmonella firis . Conclusions: Our results suggest that the supplementation in infant formulas of 2′-fucosyllactose and 6′-sialyllactose, actually commercially available and absent in cow milk, could play positive effects in artificially fed infants.