Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for colon cancer. (1st November 2016)
- Record Type:
- Journal Article
- Title:
- Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for colon cancer. (1st November 2016)
- Main Title:
- Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for colon cancer
- Authors:
- Guo, Zhanjun
Zhao, Shengnan
Fan, Haiyan
Du, Yanming
Zhao, Yufei
Wang, Guiying - Abstract:
- Abstract: The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in a number of cancers. We investigated the colon cancer risk profile of D-Loop SNPs in a case–control study. The frequent alleles of nucleotides 73G/A, 146T/C, 195T/C, 324C/G, 16261C/T, and 16304T/C as well as the minor allele of 309C/C insert were significantly associated with an increased risk for colon cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for colon cancer risk evaluation.
- Is Part Of:
- Mitochondrial DNA. Volume 27:Number 6(2016)
- Journal:
- Mitochondrial DNA
- Issue:
- Volume 27:Number 6(2016)
- Issue Display:
- Volume 27, Issue 6 (2016)
- Year:
- 2016
- Volume:
- 27
- Issue:
- 6
- Issue Sort Value:
- 2016-0027-0006-0000
- Page Start:
- 4244
- Page End:
- 4245
- Publication Date:
- 2016-11-01
- Subjects:
- Colon cancer -- D-Loop -- mtDNA -- SNPs
- Journal URLs:
- http://www.tandfonline.com/ ↗
- DOI:
- 10.3109/19401736.2014.1003920 ↗
- Languages:
- English
- ISSNs:
- 2380-2359
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 18623.xml