1148Determinants of adherence to clinic appointments among Tuberculosis and HIV co-infected individuals, Johannesburg, South Africa. (2nd September 2021)

• Record Type: Journal Article
• Authors: Nhandara, Ruvimbo; Ayele, Birhanu; Ozougwu, Lovelyn; Sigwadhi, Lovemore; Nyasulu, Peter
• Is Part Of: International journal of epidemiology. Volume 50(2021)Supplement 1
• Publication Date: 2021-09-02
• Subjects: Epidemiology -- Periodicals; 614.4
• DOI: 10.1093/ije/dyab168.498
• Languages: English
• ISSNs: 0300-5771

Abstract

Abstract: Background: Tuberculosis (TB) is one of the leading cause of morbidity and mortality among people living with HIV/AIDS. The growing burden of TB/HIV co-infection continues to strain the healthcare system due to association with long duration of treatment. This is a catalyst for poor treatment adherence, which is a major public health challenge due to its propensity to drive drug resistance. This study evaluated the effects of treatment duration on adherence to treatment among TB/HIV co-infected patients. Method: This was a cross sectional study that involved 10427 patients' ≥18 years of age with HIV infection and co-infected with TB. We measure adherence to clinic appointments as 'good' if ≥ 90% and poor if < 90%. We used multivariate logistic regression to evaluate factors associated with adherence to clinic appointments. Results: 1528 patients were co-infected with TB, of these 17.4% of them attained good adherence to clinic appointments. Patients with TB/HIV co-infection who were on treatment for a longer period were less likely to adhere to clinic appointments (AOR: 0.98 95% CI: 0.97, 0.99). This confirms the notion that advanced disease has a negative impact on adherence to clinic attendance for follow up reviews. Conclusions: Duration on treatment among TB/HIV co-infected patients is associated with treatment adherence. It is therefore vital to reinforce public health intervention that would enhance sustained treatment adherence and mitigate its impact on development of drug resistance.