Baseline neutrophil-to-lymphocyte ratio (NLR) is associated with clinical outcome in recurrent or metastatic head and neck cancer patients treated with nivolumab. (1st February 2020)

• Record Type: Journal Article
• Authors: Ueda, Tsutomu; Chikuie, Nobuyuki; Takumida, Masaya; Furuie, Hiromi; Kono, Takashi; Taruya, Takayuki; Hamamoto, Takao; Hattori, Minoru; Ishino, Takashi; Takeno, Sachio
• Is Part Of: Acta oto-laryngologica. Volume 140:Number 2(2020)
• Page Start: 181
• Page End: 187
• Publication Date: 2020-02-01
• Subjects: Nivolumab -- head and neck cancer -- neutrophil-lymphocyte ratio -- immunotherapy -- survival rate -- PD-1 receptor; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2019.1699250
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Background: Nivolumab has been approved for recurrent or metastatic head and neck cancer (R/M HNC) on March 2017 in Japan. Recently, many researchers have been actively studying the prognostic and predictive markers. However, they have not been clarified. In this study, we evaluate the prognostic and predictive markers of the anticancer effect of nivolumab. Objective: This study assessed baseline neutrophil-to-lymphocyte ratio (NLR) as a prognostic and predictive marker for nivolumab efficacy in patients with recurrent/metastatic head and neck cancer (R/M HNC). Material and methods: This retrospective cohort study used medical records of patients with R/M HNC treated with nivolumab from May 2017 to January 2018 at a university hospital in Japan. Results : Twenty-nine patients (median age, 64 years) were included. In univariate analyses, baseline NLR ≥5 was significantly associated with overall survival (HR 4.88; p = .045) and progressive disease (HR 5.0; p = .046). More patients with baseline NLR ≥5 changed from nivolumab to best supportive care, compared to patients with baseline NLR <5 (64.3% vs 26.7%, respectively). Conclusions and significance: Baseline NLR was associated with clinical benefit from nivolumab in patients with R/M HNC. We propose that baseline NLR be used as a predictive or prognostic marker for nivolumab efficacy in these patients.