PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing. Issue 2 (15th March 2017)

• Record Type: Journal Article
• Authors: Fuchs, Alisa; Torroba, Marcos; Kinkley, Sarah
• Is Part Of: Transcription. Volume 8:Issue 2(2017)
• Page Start: 106
• Page End: 112
• Publication Date: 2017-03-15
• Subjects: bivalency and H3K4me3 -- co-transcriptional splicing -- PHF13 -- polycomb repressive complex 2 (PRC2) -- RNA polymerase II -- RNA polymerase II pausing -- SPOC1 -- transcriptional regulation; Genetic transcription -- Periodicals; 572.8
• DOI: 10.1080/21541264.2016.1274813
• Languages: English
• ISSNs: 2154-1264

Abstract

ABSTRACT: We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.