Evaluation of the antioxidant and anti-inflammatory activities of solvent extracts of Tricholepis chaetolepis (Boiss) Rech. f. whole plant. Issue 4 (16th February 2020)

• Record Type: Journal Article
• Authors: Abbas, Ali; Hassan, Syed Saeed-ul; Sharif, Ali; Ahmed, Shoaib
• Is Part Of: Natural product research. Volume 34:Issue 4(2020)
• Page Start: 575
• Page End: 579
• Publication Date: 2020-02-16
• Subjects: Tricholepis chaetolepis -- anti-diabetic -- anti-oxidant -- inflammation; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1490905
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The whole plant, Tricholepis chaetolepis, powder was investigated using proximate and fluorescence analysis along with determining the extractive values. Total phenolics, flavonoids and total protein contents of n-hexane, chloroform and methanolic extracts of the whole plant were also determined. The anti-diabetic activity of all the three extracts of the plant was determined by in vitro alpha-amylase inhibition assay. The anti-oxidant potential was evaluated using Phosophomolybdenum and DPPH methods. The anti-inflammatory potential of all extracts were determined by carrageenan-induced rat paw oedema model. The evaluation of the plant extracts exhibited the anti-diabetic, anti-oxidant, and anti-inflammatory activities in dose dependent fashion. The research concludes that Tricholepis chaetolepis extracts contain phenol, flavonoids, and tannins that show observable anti-oxidant and anti-diabetic potential. It is also concluded that the methanol extract of the plant showed the maximum effect against inflammation induced by carrageenan in rat paw oedema as compared with n-hexane and chloroform extracts. Graphical Abstract: